Phenylpropanoids and polyketides
Apexbio Technology LLC AST 487 630124-46-8 5mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Medchemexpress LLC m-Coumaric acid (Standard) | 588-30-7 | 99.9% | 164.16 | 50 MG
m-Coumaric acid (Standard) is an analytical standard intended for research and analytical applications. It is a polyphenol metabolite from caffeic acid, formed by gut microflora, and is BBB-penetrant (blood-brain barrier) from chlorogenic acid.
- Stimulates cerebral nerves in vitro
- Evokes neurite outgrowth in hippocampal neuronal cells
- Promotes neuronal differentiation
- Increases spontaneous locomotor activity in mice
- Inhibits the oxidation of L-dopa by epidermis tyrosinase
- Attenuates non-catalytic protein glycosylation in retinas of diabetic rats
- Used as an analytical standard in HPLC, GC, and MS research experiments
Research Products International Corp Myricetin 10 MG
Myricetin is a naturally occurring flavonol, a flavonoid found in many grapes, berries, fruits, vegetables, herbs as well as other plants.
Apexbio Technology LLC Palomid 529 914913-88-5 50mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Apexbio Technology LLC Entacapone 130929-57-6 100mg
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
eMolecules 492-14-8 | Medchem Express | (-)-Butin | 1mg | 705861649 | HY-N6020 | MFCD21606964 | 272.256 | C15H12O5
Medchem Express | Maxacalcitol-d6 | 1mg | 446265465 | HY-15329 | | MFCD22417101 | 424.655 | C26H42O4
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Medchemexpress LLC 14,15-EE-5(Z)-E | 519038-92-7 | >98.0% | 50UG
14,15-EE-5(Z)-E | 519038-92-7 | >98.0% | 50UG
Medchemexpress LLC 1-(2-dimethylaminoethyl)-1,2,3,4-tetrahydro-2-methylcarbazole hydrochloride | 54-84-2 | MFCD00055609 | 99.5% | 376.9 g/mol | C20H25ClN2OS | 1 ML
Cinanserin hydrochloride is the hydrochloride salt of cinanserin, supplied for research use as a 10 mM solution in DMSO (1 mL) and as solid quantities. It functions as a 5-HT2 receptor antagonist in pharmacological and biochemical studies and is provided with supporting documentation for quality control.
- Provided as 10 mM solution in DMSO (1 mL) and as solid pack sizes.
- High purity suitable for biochemical and pharmacological assays.
- Accompanied by a datasheet and certificate of analysis.
- Used as a 5-HT2 receptor antagonist in research applications.
- CAS number 54-84-2 for unambiguous chemical identification.
- Molecular weight 376.9 g/mol.
TARGETMOL CHEMICALS INC SAR405 R enantiomer 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.SAR405 (R enantiomer) is the less active form of SAR405, an inhibitor of PIK3C3/Vps34. Purity 98.04%
TARGETMOL CHEMICALS INC Catechin 10MG
Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. (-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 uM. Purity 98.06%
Pfaltz & Bauer 2 4-Dimethoxycinnamic Acid 97 25G | 6972-61-8
2 4-Dimethoxycinnamic Acid 97 25G | 6972-61-8
eMolecules 36651-81-7 | 5-Methyl-8-hydroxycoumarin | Synthonix - Stock | MFCD18450566 | 176.171 | C10H8O3 | 95.000 | Cc1ccc(O)c2oc(=O)ccc12 | 1g | 495880208
5-Methyl-8-hydroxycoumarin | Synthonix - Stock | 36651-81-7 | MFCD18450566 | 176.171 | C10H8O3 | 95.000 | Cc1ccc(O)c2oc(=O)ccc12 | 1g | 495880208